I used to be a heavy drinker and then I stopped at around 30 years of age. It affected my health, my career and my personal relationships.
I still enjoy going out and spending time with friends. Not drinking is not really an issue for me, as the benefits of a healthier life far outpace any kind of fun I could still get out of drinking, and let’s not even start on the hangovers. You can maybe call this maturing.
An unpleasant side effect is the lacking relationship with my drinker friends. While in my snobbish non-drinking life I can enjoy an opera event, hiking, as well as activities that usually involve drinking like watching football, in stadium or pub, for my drinking friends, the time spent is a bit sour.
Not being synched on drinking and drunkenness level creates a gap in the jokes, the arguments, subjects and so on. I do remember myself, that drinking with a teetotaler is an immediate turn off. For me it was always saying something stupid, that might sound okayish to an equally drunk person, but completely offensive to a sober person.
This begs the question, if the activity in itself is still worth going for, as I don't get as much out of it, especially as people get drunker later in the night, and it also decreases their joy.